Administration of ALA is safe and well-tolerated in most patients. Side effects are rare but can include low blood sugar, nausea. vomiting, vertigo, gastric upset and allergic reactions. With any intravenous infusion there is risk of pain and inflammation at the injection site as well as risk of infiltration lV fluid leaking outside of the veins.
High doses of ALA have been administered in multiple studies and there have been no documented fatal overdoses or severe reactions to ALA in the literature.
Due to the hypoglycemia effects of ALA caution should be advised in diabetics who are receiving ALA Diabetics receiving ALA should closely monitor their blood glucose levels. One study found that ALA administration is safe in diabetic patients with hepatic impairment